The Guildford departed Cork on 14 November 1817 and arrived in Port Jackson on 1 April 1818
The Coromandel departed Spithead on 1 November 1819 and arrived in Port Jackson on 4 April 1820.
Appointed to Committee of Enquiry 1820
In a circular dated 26 April 1820 Archibald Hume, James Marr Brydone and James Hunter all Royal Navy Surgeons were requested to investigate the increase in disease and consequent mortality prevailing in the colony at the time in particular in Sydney and the General Hospital. The Governor sought their professonal opinions and advice into the probable causes and the most effectual means of counter-acting its progress and requested a Committee of Enquiry be established. The meeting was postponed, at least for a time because of the absence of James M. Brydone and James Hunter. 
Archibald Hume was still in the colony in July 1821, however had returned to Scotland by 1822 -
Edinburgh Museum.—We understand that Mr Archibald Hume, Surgeon, R. N. has lately presented to the Museum of the Royal College of Surgeons of this city, a fine specimen of the head of a young New Zealand Chief, beautifully tattooed and embalmed, in a manner unknown to the civilized nations of modern times, but which commands the admiration of all adequate judges. Mr Hume has promised to communicate to the College an account of the mode in which the process is conducted.